Functional assessments demonstrated that PBM markedly preserved both short-term (a week) and long-term (6 months) spatial learning and memory function following GCI. It was noted that PBM dose-dependently protected against GCI-induced neuronal death in the vulnerable hippocampal CA1 subregion. In this study, we evaluated the therapeutic effects of PBM treatment with an 808-nm diode laser initiated 6 h after GCI. PBM involves the use of low-level laser light therapy to influence cell behavior. As a noninvasive procedure, photobiomodulation (PBM) therapy has emerged as a potential novel treatment for brain injury.
Hypothermia is currently the only approved therapy for global cerebral ischemia (GCI) after cardiac arrest however, it unfortunately has multiple adverse effects.
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